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Strict Standards: Non-static method Jetpack_Data::get_access_token() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 277

Strict Standards: Non-static method Jetpack::get_option() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3504

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Strict Standards: Non-static method Jetpack::get_option_names() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 477

Strict Standards: Non-static method Jetpack::get_option_names() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 479

Strict Standards: Non-static method Jetpack::get_active_modules() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 358

Strict Standards: Non-static method Jetpack::get_option() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 825

Strict Standards: Non-static method Jetpack::get_option_names() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 477

Strict Standards: array_filter() expects parameter 2 to be a valid callback, non-static method Jetpack::is_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 358

Strict Standards: Non-static method Jetpack::get_available_modules() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 837

Strict Standards: Non-static method Jetpack::glob_php() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 707

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 712

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 716

Strict Standards: Non-static method Jetpack::get_available_modules() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 837

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

Strict Standards: Non-static method Jetpack::get_module() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 364

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Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 804

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Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3813

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4409

Strict Standards: Non-static method Jetpack_Data::get_access_token() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 277

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4409

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Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3813

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4409

Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3788

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4050

Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3802

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4250

Strict Standards: Non-static method Jetpack_Subscriptions::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/subscriptions.php on line 511

Strict Standards: Non-static method Jetpack::init() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/subscriptions.php on line 56

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 383

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Strict Standards: Non-static method Jetpack::glob_php() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/shortcodes.php on line 38

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 383

Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3788

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4050

Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3802

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4250

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 383

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Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3813

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4409

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 383

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Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4409

Strict Standards: Non-static method Jetpack_Notifications::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/notes.php on line 154

Strict Standards: Non-static method Jetpack::init() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/notes.php on line 42

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Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3802

Strict Standards: Non-static method Jetpack::get_module_slug() should not be called statically, assuming $this from incompatible context in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 4250

Strict Standards: Non-static method Jetpack::get_module_path() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 383

Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3802

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Strict Standards: Non-static method Jetpack::init() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/jetpack.php on line 3788

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Strict Standards: Non-static method Jetpack::enable_module_configurable() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/widgets.php on line 18

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Strict Standards: Non-static method Jetpack::enable_module_configurable() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/gravatar-hovercards.php on line 22

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Strict Standards: Non-static method Jetpack::enable_module_configurable() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/subscriptions.php on line 29

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Strict Standards: Non-static method Jetpack::enable_module_configurable() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/sharedaddy.php on line 16

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Strict Standards: Non-static method Jetpack::enable_module_configurable() should not be called statically in /home/content/51/9126351/html/vidznet.com/blog/wp-content/plugins/jetpack/modules/after-the-deadline.php on line 12

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Nanoparticles Show Potential for Treating MS

Nanoparticles Show Potential for Treating MS

scientist at work

Nov. 18, 2012 — Researchers say they’ve been able to use nanoparticles to stop multiple sclerosis (MS) in mice that are bred to have the disease.

The particles are about 200 times smaller than the thickness of a human hair. They are made from the same material that’s used to create dissolving stitches.

When researchers attach specific proteins to the particles, they say they’re able to teach the body not to attack its own tissues.

If the approach succeeds in human studies, it may one day lead to more targeted treatments not only for multiple sclerosis but also for other kinds of autoimmune disorders, including type 1 diabetes and rheumatoid arthritis.

The research is published in the journal Nature Biotechnology. The study was funded by grants from the National Institutes of Health, the Myelin Repair Foundation, the Juvenile Diabetes Foundation, and the Australian government.

Slideshow: A Visual Guide to Multiple Sclerosis

Turning Down an Autoimmune Attack

In multiple sclerosis, the body attacks its own myelin. Like the insulation around electric wires, myelin is a material that coats nerve fibers, allowing them to effectively carry signals that power the body.

Over time, people with MS may develop a host of problems related to myelin damage, including trouble with muscle coordination, movement, numbness, pain, and vision problems. About 80% of people with MS have the relapsing-remitting form. The mice in this study were bred to have this type of MS.

Researchers wondered if they could stop that process by making use of the body’s “garbage disposal system.” In addition to protecting the body from foreign invaders, an important role of the immune system is getting rid of dead cells.

When dead or dying cells pass through the spleen, big white blood cells called macrophages gobble them up. As part of this process the macrophages send signals to other parts of the immune system, letting them know that the dying cells aren’t dangerous, just routine bits of trash that need to go.

Years ago, researcher Stephen D. Miller, PhD, an immunologist in the Feinberg School of Medicine at Northwestern University in Chicago, figured that it might be possible to hijack this garbage removal system and get the body to recognize — and then ignore — proteins it was mistaking for threats.

“What we’ve done is simply tap into a system that the immune system was smart enough to evolve millions of years ago to get rid of dead and dying cells,” Miller says.

He’s already tried the approach in humans using white blood cells that were first collected and then killed. He then attached proteins to the dying cells and infused them into the body. In an early safety trial, Miller says that approach appeared to be well tolerated.

“There [were no side effects], there was no re-triggering of disease, and we actually showed that immune responses in patients were decreased,” Miller says.

But other immune responses, such as protection against certain infections, remained strong. That suggests that patients treated this way wouldn’t see the kind of general immune suppression that happens with current treatments for autoimmune diseases.

Article source: http://www.webmd.com/multiple-sclerosis/news/20121115/nanoparticles-show-potential-for-treating-ms?src=RSS_PUBLIC

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